Synthesis of the biologically important dideuterium-labelled adenosine triphosphate analogue ApppI(d₂)

• Petri A. Turhanen

Beilstein J. Org. Chem. 2022, 18, 1466–1470, doi:10.3762/bjoc.18.153

• Petri A. Turhanen University of Eastern Finland, School of Pharmacy, Biocenter Kuopio, P.O. Box 1627, FIN-70211, Kuopio, Finland 10.3762/bjoc.18.153 Abstract The chemical synthesis of the dideuterium-labelled ATP analogue 1-adenosin-5’-yl-3-(3-methylbut-3-en-1,1-d2-1-ol) triphosphoric acid

• deuterium-labelled highly important ATP analogue ApppI(d2) has been described in detail. This leaves the possibility to develop a quantitative MS method for the determination of ApppI in biological samples by using ApppI(d2) as internal standard. Samples of ApppI(d2) are available from the author upon

Two strategies for the synthesis of the biologically important ATP analogue ApppI, at a multi-milligram scale

• Janne Weisell,
• Jouko Vepsäläinen and
• Petri A. Turhanen

Beilstein J. Org. Chem. 2015, 11, 2189–2193, doi:10.3762/bjoc.11.237

• characterized by 1H, 13C, 31P NMR and MS spectroscopical methods. Keywords: ApppI; ATP analogue; HPLC; purification; synthesis; Findings Bisphosphonates (BPs), which are stable analogues of pyrophosphate occurring in cells, have been used for decades for the treatment of many kinds of bone related diseases